CoffeeCup Image Mapper has mouseover HTML capability, includes a fully functional image map wizard, and enables users to attach parts of an image to different links.
Image Mapper can map any noninterlaced GIF, interlaced GIF, standard JPEG, and progressive JPEG, PNG as well as the first frame of an animated GIF. Users can choose from three different shape methods for mapping those hard-to-reach spots. Image Mapper supports mouseover pop-up tags, frame targeting, image previewing, and link and mouseover memory.
15 day free trial for Windows Vista and XP.